Morpholine → HCID 18681135, compound

HRID 276008Notes

Reaction equation

HRID 276008 reaction equation
Cl.[Cl:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([C:15](Cl)=[O:16])[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH:18]1[CH2:20][CH2:19]1.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>C(Cl)Cl>[Cl:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([C:15]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[O:16])[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH:18]1[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 18680910HCID 18680910, compound

Product 1

HCID 18681135HCID 18681135, compoundYield 13.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(2-Chlorobenzyl)-6-chlorocarbonyl-2-cyclopropylbenzimidazole hydrochloride (140 mg) was added to a solution prepared by adding 298 mg of morpholine (30% methanol solution) to 10 ml of methylene chloride at room temperature. The reaction mixture was stirred at the same temperature for 1 hour, then washed with water, dried, and concentrated under reduced pressure. The residue was recrystallized with ether to give 20 mg of 1-(2-chlorobenzyl)-2-cyclopropyl-6-morpholinocarbonylbenzimidazole (66).

Workup

  1. customprepared
  2. washwashed with water
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was recrystallized with ether

Sources & evidence

ORD record
ord-34e00dd2863640fcb1aee7d78c3c7925
Source dataset
uspto-grants-2002_03
Patent number
US06352985B1

Reaction notes

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