Potassium Bicarbonate → HCID 69689811, compound

Participants

Reaction Steps

Five-percent palladium on carbon (0.64 g) was added to a mixture containing 4.27 g of N-benzenesulfonyl-3-(biphenyl-4-ylmethylamino)-4-nitrobenzamide potassium salt, 10.7 g of a 20% potassium hydrogencarbonate aqueous solution and 200 ml of methanol, and the mixture was stirred in a hydrogen atmosphere at 35° C. for 14 hours. The crystals precipitated were dissolved in 400 ml of a mixed solution of acetone and water (at a ratio of 5:2). The solid material was separated through filtration. The filtrate was concentrated, and the crystals precipitated were separated through filtration, and were dried to give 3.15 g of N-benzenesulfonyl-4-amino-3-(biphenyl-4-ylmethylamino)benzamide potassium salt.

Provenance & Evidence