反应详情

Five-percent palladium on carbon (2.53 g) was added to a solution of 10.0 g of N-(2-pyridylmethyl)-4-acetylamino-3-nitrobenzamide in 150 ml of methanol, and the mixture was stirred in a hydrogen atmosphere at 60° C. for 15 hours. The solid material was separated through filtration, and the filtrate was concentrated. The resulting residue was purified through silica-gel column chromatography (eluent: a mixture of ethyl acetate and methanol at a ratio of 7:3) to give 8.02 g of N-(2-pyridylmethyl)-4-acetylamino-3-aminobenzamide.

1. customThe solid material was separated through filtration
2. concentrationthe filtrate was concentrated
3. customThe resulting residue was purified through silica-gel column chromatography (eluent
4. additiona mixture of ethyl acetate and methanol at a ratio of 7:3)