反应详情

A solution of 7 ml of methanol containing 0.60 g of N-benzenesulfonyl-4-acetylamino-3-aminobenzamide, 0.656 g of 2,4-difluorobenzyl bromide and 0.423 g of potassium hydrogencarbonate was stirred at 60° C. for 1 hour. The reaction solution was concentrated, and the residue was purified through silica-gel column chromatography (eluent: a mixture of ethyl acetate and methanol at a ratio of 9:1) to give 0.370 g of N-benzenesulfonyl-4-acetylamino-3-(2,4-difluorobenzylamino)benzamide.

1. concentrationThe reaction solution was concentrated
2. customthe residue was purified through silica-gel column chromatography (eluent
3. additiona mixture of ethyl acetate and methanol at a ratio of 9:1)