Hydrochloric Acid → 6-Carboxy-1-(2-Chlorobenzyl)-2-Methylbenzimidazole

Participants

Reaction Steps

Ethanol (15 ml) and 10.6 g of a 5% sodium hydroxide aqueous solution were added to 1.456 g of 1-(2-chlorobenzyl)-6-ethoxycarbonyl-2-methylbenzimidazole, and the mixture was refluxed for 1 hour. The reaction solution was cooled, and was then adjusted to a pH of 6 with 10% hydrochloric acid. The precipitate was collected, washed with water, and dried under reduced pressure to give 0.645 g of 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole (121).

Provenance & Evidence