反应详情

Five milliliters of thionyl chloride were added to 3.56 g of 1-(2-chlorobenzyl)-6-hydroxymethyl-2-methylbenzimidazole, and the mixture was stirred at room temperature for 20 minutes and then at 80° C. for 20 minutes. After excess thionyl chloride was distilled off under reduced pressure, the residue was dissolved in 10 ml of chloroform, and the solution was crystallized from hexane. The crystals were separated through filtration, washed with hexane, and dried to give 4.07 g of 1-(2-chlorobenzyl)-6-chloromethyl-2-methylbenzimidazole hydrochloride.

1. waitat 80° C. for 20 minutes
2. distillationAfter excess thionyl chloride was distilled off under reduced pressure
3. dissolutionthe residue was dissolved in 10 ml of chloroform
4. customthe solution was crystallized from hexane
5. customThe crystals were separated through filtration
6. washwashed with hexane
7. customdried