Hydrochloric Acid → 6-Carboxy-1-(2-Chlorobenzyl)-2-Methylbenzimidazole

Participants

Reaction Steps

To 60.0 g of 1-(2-chlorobenzyl)-6-ethoxycarbonyl-2 -methylbenzimidazole were added 240 g of a 10% sodium hydroxide aqueous solution and 200 ml of ethanol, and the mixture was heat-refluxed for 2 hours. The reaction solution was cooled, and was then adjusted to a pH of 6 with 10% hydrochloric acid. The crystals precipitated were separated through filtration, and were dried to give 54.7 g of 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole (121).

Provenance & Evidence