참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Tetramethyl orthocarbonate | HCID 74613 | — |
| 반응물 | N-benzenesulfonyl-4-amino-3-(biphenyl-4-ylmethylamino)benzamide | HCID 53635937 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 6-Benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)-2-methoxybenzimidazole | HCID 53959924 | 64.4% |
반응 단계
Tetramethoxymethane (0.250 g) was added to a solution of 0.400 g of N-benzenesulfonyl-4-amino-3-(biphenyl-4-ylmethylamino)benzamide in 3 ml of acetic acid, and the mixture was stirred at 80° C. for 2 hours. Methanol was added to the reaction solution, and the crystals precipitated were collected. The crystals were washed with a mixed solvent of 1 ml of acetone and 8 ml of methanol, separated through filtration, and dried to give 0.280 g of 6-benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)-2-methoxybenzimidazole (228).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06352985B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_03 |
|---|
| ORD ID | ord-cb47edb644c341e9b0eddb957c568990 |
|---|
| 출처 메모 | uspto-grants-2002_03 |
|---|
