Formic Acid → 6-Benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)benzimidazole

HRID 276054Notes

Reaction equation

HRID 276054 reaction equation
[C:1]1([S:7]([NH:10][C:11](=[O:33])[C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([NH:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:23][CH:22]=3)[CH:13]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:34](O)=O>>[C:1]1([S:7]([NH:10][C:11]([C:12]2[CH:17]=[CH:16][C:15]3[N:18]=[CH:34][N:19]([CH2:20][C:21]4[CH:26]=[CH:25][C:24]([C:27]5[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=5)=[CH:23][CH:22]=4)[C:14]=3[CH:13]=2)=[O:33])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 53635937N-benzenesulfonyl-4-amino-3-(biphenyl-4-ylmethylamino)benzamide

Product 1

HCID 537801916-Benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)benzimidazole

Conditions

Temperature
90 °C

Procedure

A mixture of 0.400 g of N-benzenesulfonyl-4-amino-3-(biphenyl-4-ylmethylamino)benzamide and 2 ml of formic acid was stirred at 90° C. for 3 hours. The reaction solution was concentrated, and was precipitated with methanol. The crystals precipitated were separated through filtration, and were dried to give 0.243 g of 6-benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)benzimidazole (241).

Workup

  1. concentrationThe reaction solution was concentrated
  2. customwas precipitated with methanol
  3. customThe crystals precipitated
  4. customwere separated through filtration
  5. customwere dried

Sources & evidence

ORD record
ord-268aa189edc54ba695839d320685ed25
Source dataset
uspto-grants-2002_03
Patent number
US06352985B1

Reaction notes

Loading…