反应详情

温度

90 °C

A mixture of 0.400 g of N-benzenesulfonyl-4-amino-3-(biphenyl-4-ylmethylamino)benzamide and 2 ml of formic acid was stirred at 90° C. for 3 hours. The reaction solution was concentrated, and was precipitated with methanol. The crystals precipitated were separated through filtration, and were dried to give 0.243 g of 6-benzenesulfonylcarbamoyl-1-(biphenyl-4-ylmethyl)benzimidazole (241).

1. concentrationThe reaction solution was concentrated
2. customwas precipitated with methanol
3. customThe crystals precipitated
4. customwere separated through filtration
5. customwere dried