反应详情

温度

90 °C

Four milliliters of acetic acid and 8 ml of ethanol were added to 0.434 g of N-(2-pyridylmethyl)-4-acetylamino-3-(4-benzyloxybenzylamino)benzamide, and the mixture was stirred at 90° C. for 7 hours. The reaction solution was concentrated under reduced pressure. Ethyl acetate and ether were added to the residue for crystallization. The crystals were separated through filtration, and were dried to give 0.375 g of 1-(4-benzyloxybenzyl)-2-methyl-6-[(2-pyridylmethyl)carbamoyl]-benzimidazole (242).

1. concentrationThe reaction solution was concentrated under reduced pressure
2. additionEthyl acetate and ether were added to the residue for crystallization
3. customThe crystals were separated through filtration
4. customwere dried