反应详情

温度

70 °C

Two milliliters of acetic acid and 5 ml of methanol were added to 0.490 g of N-(2-pyridylmethyl)-4-acetylamino-3-(3,4-methylenedioxybenzylamino)benzamide, and the mixture was stirred at 70° C. for 8 hours. The reaction solution was concentrated under reduced pressure. The residue was purified through silica-gel column chromatography (eluent: a mixture of ethyl acetate and methanol at a ratio of 9:1), and was then crystallized from ethyl acetate. The crystals were separated through filtration, and were dried to give 0.270 g of 2-methyl-1-(3,4-methylenedioxybenzyl)-6-[(2-pyridylmethyl)carbamoyl]-benzimidazole (243).

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customThe residue was purified through silica-gel column chromatography (eluent
3. additiona mixture of ethyl acetate and methanol at a ratio of 9:1), and
4. customwas then crystallized from ethyl acetate
5. customThe crystals were separated through filtration
6. customwere dried