HCID 54055502, compound → HCID 18681167, compound

Participants

Reaction Steps

5% Palladium on carbon (0.500 g) was added to a solution of 0.607 g of N-benzenesulfonyl-1-(2-chlorobenzyl)-2-methylbenzimidazole-6-acrylamide in 150 ml of ethanol, and the mixture was stirred in a hydrogen atmosphere at room temperature for 43 hours. The solid material was separated through filtration, and the filtrate was concentrated. The residue was dissolved in a mixed solution of a 20% potassium hydrogencarbonate aqueous solution and methanol, and was adjusted to a pH of from 5 to 6 with 10% hydrochloric acid. The crystals precipitated were separated through filtration, and was dried to give 0.250 g of N-benzenesulfonyl-3-[1-(2-chlorobenzyl)-2-methylbenzimidazol-6-yl]propionamide (266).

Provenance & Evidence