反应详情

A mixture of 8.70 g of 2-fluoro-4′-methylbiphenyl, 8.32 g of N-bromosuccinimide, 0.10 g of 2,2′-azobisisobutylonitrile and 150 ml of carbon tetrachloride was heat-refluxed for 5 hours. The reaction solution was washed with water, and the organic layer was concentrated. The resulting residue was purified through silica-gel column chromatography (eluent: a mixture of hexane and ethyl acetate at a ratio of 9:1) to obtain crude 2-fluoro-4′-bromomethylbiphenyl. Further, this compound was crystallized from hexane to give 4.93 g of 2-fluoro-4′-bromomethylbiphenyl.

1. temperaturewas heat-refluxed for 5 hours
2. washThe reaction solution was washed with water
3. concentrationthe organic layer was concentrated
4. customThe resulting residue was purified through silica-gel column chromatography (eluent
5. additiona mixture of hexane and ethyl acetate at a ratio of 9:1)
6. customto obtain crude 2-fluoro-4′-bromomethylbiphenyl
7. customFurther, this compound was crystallized from hexane