2-Bromoethanol → HCID 18316809, compound

Participants

Reaction Steps

0.1 mol of 3-(n-butyl-amino)phenol in 100 ml of methanol is refluxed for 10 h with 0.11 mol of 2-bromoethanol and 0.1 mol of NaHCO3. After cooling, the mixture is filtered, the solvent is removed in vacuo and the residue is fractionated, to give 3-[N-(n-butyl)-N-(2-hydroxyethyl)amino]-phenol in a yield of 54%; b.p. 130-140° C. (5·10−5 torr), m.p. 45-47° C.

Provenance & Evidence