Lithium Hydroxide → HCID 6971045, compound

Participants

Reaction Steps

A solution of aqueous LiOH (0.3M, 20 mL) was added dropwise to a solution containing Compound 10 (0.52 g, 1.34 mmol) in THF-H2O (3:1, 22 mL). From TLC, the reaction was complete within 30 minutes. Dowex® 50W-X8[H+] was added to neutralize the solution, then the resin was filtered off, and the filtrate was concentrated. The product was purified by flash column chromatography with CHCl3—MeOH (3.5:1) to obtain 0.29 g (1.3 mmol) of Compound 11 (97 percent yield). Further purification was carried out with Bio Gel P-2 chromatography using water as eluent.

Provenance & Evidence