Hydrogen Peroxide → 3-Phenoxyphenylacetamide

Participants

Reaction Steps

3-Phenoxyphenylacetonitrile (1.0 g; 4.8 mmol) was dissolved in DMSO (3 mL) and cooled in an ice-water bath. Potassium carbonate (0.2 g; 1.5 mmol) was added, followed by dropwise addition of 1.0 mL of 30% hydrogen peroxide. The bath was removed, and the mixture allowed to warm to room temperature while stirring for 40 min. Water was added, and the product isolated as a white crystalline solid by filtration, and washed with fresh water. mp 115-117° C.

Provenance & Evidence