HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 4-Benzylphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Product | 4-Benzylphenylacetonitrile | HCID 597531 | 33% |
| Product | 3-Benzyl-1-cyanomethylbenzene | HCID 18317010 | 9.2% |
Reaction Steps
The crude bromomethylbenzene intermediate (19.6 g, 75 mmole) was treated with NaCN as in Example 2 and, after chromatography over silica gel (10 to 100% EtOAc in hexane), 5.2 g (33%) of 4-benzyl-l-cyanomethylbenzene and 1.43 g (9.2%) of 3-benzyl-1-cyanomethylbenzene were obtained, both as oils.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353128B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-b9cca87a9ae643d0aae58d57f05daa44 |
| Source note | uspto-grants-2002_03 |