Chlorotrimethylsilane → (E)-3-cycloheptyl-2-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-acrylic acid methyl ester

Temperature

25 °C

A mixture of zinc dust (390 mg, 6 mmol, Aldrich, −325 mesh) and dry tetrahydrofuran (1 mL) under argon was treated with 1,2-dibromoethane (94 mg, 0.5 mmol). The zinc suspension was then heated with a heat gun to ebullition, allowed to cool, and heated again. This process was repeated three times to make sure the zinc dust was activated. The activated zinc dust suspension was then treated with trimethylsilyl chloride (55 mg, 0.5 mmol), and the suspension was stirred for 15 min at 25° C. The reaction mixture was then treated dropwise with a solution of (E)-3-cycloheptyl-2-iodo-acrylic acid methyl ester (prepared in Example 5, 616 mg, 2 mmol) in dry tetrahydrofuran (2 mL). After the addition, the reaction mixture was stirred for 1 h at 40-45° C. and then stirred overnight at 25° C. The reaction mixture was then diluted with dry tetrahydroftiran (2 mL), and the stirring was stopped to allow the excess zinc dust to settle down (˜2 h). In a separate reaction flask, bis(dibenzylideneacetone)palladium(0) (27 mg, 0.05 mmol) and triphenylphosphine (52 mg, 0.2 mmol) in dry tetrahydrofuran (4 mL) was stirred at 25° C. under argon for 10 min and then treated with 4-bromo-1-methanesulfonyl-2-trifluoromethyl-benzene (prepared in Example 12, 303 mg, 1 mmol) and the freshly prepared zinc compound in tetrahydrofuran. The resulting brick red solution was heated at 40-45° C. for 24 h. The reaction mixture was cooled to 25° C. and then poured into a saturated aqueous ammonium chloride solution (30 mL), and the organic compound was extracted into ethyl acetate (3×25 mL). The combined organic extracts were washed with a saturated aqueous sodium chloride solution (1×100 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. Biotage chromatography (FLASH 40M, Silica, 4/1 hexanes/ethyl acetate) afforded (E)-3-cycloheptyl-2-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-acrylic acid methyl ester (387 mg, 95%) as a viscous oil.

1. temperatureto cool
2. temperatureheated again
3. additionAfter the addition
4. stirringthe reaction mixture was stirred for 1 h at 40-45° C.
5. stirringstirred overnight at 25° C
6. additionThe reaction mixture was then diluted
7. customwith dry tetrahydroftiran (2 mL)
8. custom(˜2 h)
9. stirringwas stirred at 25° C. under argon for 10 min
10. temperatureThe resulting brick red solution was heated at 40-45° C. for 24 h
11. temperatureThe reaction mixture was cooled to 25° C.
12. extractionthe organic compound was extracted into ethyl acetate (3×25 mL)
13. washThe combined organic extracts were washed with a saturated aqueous sodium chloride solution (1×100 mL)
14. dry with materialdried over anhydrous magnesium sulfate
15. filtrationfiltered
16. concentrationconcentrated in vacuo

ORD record

ord-4e3aa40546d8492e8f2c4c95c24ef65f

Source dataset

uspto-grants-2002_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06353111B1