反应详情

An 80.0 g. portion of the above nitro derivative in 800 ml. of acetone is added to 320.0 g. of sodium hydrosulfite in 800 ml. of water. The mixture is heated to reflux on a steam bath for one hour, cooled and extracted with benzene. The benzene extract is washed with water, dried over anhydrous sodium sulfate, and evaporated in vacuo to a yellow oil. Treatment in hexane, with cooling produces crystals of 5-chloro-2-(p-methoxyphenoxy)-aniline.

1. temperatureThe mixture is heated
2. temperatureto reflux on a steam bath for one hour
3. temperaturecooled
4. extractionextracted with benzene
5. extractionThe benzene extract
6. washis washed with water
7. dry with materialdried over anhydrous sodium sulfate
8. customevaporated in vacuo to a yellow oil
9. temperatureTreatment in hexane, with cooling