2-Methyl-4-nitrophenyl isothiocyanate → HCID 22951405, compound

HRID 276318Notes

Reaction equation

HRID 276318 reaction equation
[Cl-].Cl[CH2:3][CH2:4][NH2+:5][CH:6]([CH2:8][CH3:9])[CH3:7].[CH3:10][C:11]1[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=1[N:20]=[C:21]=[S:22]>>[CH3:10][C:11]1[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=1[N:20]=[C:21]1[N:5]([CH:6]([CH2:8][CH3:9])[CH3:7])[CH2:4][CH2:3][S:22]1

Participants

3

Reactant 2

HCID 1456212-Methyl-4-nitrophenyl isothiocyanateHCID 86590171HCID 86590171, compound

Product 1

HCID 22951405HCID 22951405, compound

Procedure

2-Butylamine was converted to N-(2-hydroxyethyl)-N-(2-butyl)amine according to Method B5a. The amine was reacted with SOCl2 according to Method B7a to give N-(2-chloroethyl)-N-(2-butyl)ammonium chloride. The chloroethylamine was reacted with 2-methyl-4-nitrophenyl isothiocyanate according to Method C1a to give to give 2-(2-methyl-4-nitrophenylimino)-3-(2-butyl)-1,3-thiazolidine.

Workup

  1. customto give

Sources & evidence

ORD record
ord-10a38278245b4b80b35d6ccbadde578d
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Reaction notes

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