HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-((Cyclobutylmethyl)amino)ethanol | HCID 18316306 | — |
| Product | N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride | HCID 18316353 | — |
Reaction Steps
2-Hydroxyethylamine was reacted with cyclobutylmethyl bromide according to Method B2a to give N-cyclobutylmethyl-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 3-chloro-2-methylphenyl isothiocyanate to give 2-(3-chloro-2-methylphenylimino)-3-(cyclobutylmethyl)-1,3-thiazolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-1a81873fd33c473b8528a91e676bc489 |
| Source note | uspto-grants-2002_03 |