HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-(4-chlorobenzyl)-N-(2-chloroethyl)ammonium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(4-Chloro-benzylamino)-ethanol | HCID 424452 | — |
| Product | N-(4-chlorobenzyl)-N-(2-chloroethyl)ammonium chloride | HCID 18316438 | — |
Reaction Steps
2-Hydroxyethylamine was reacted with 4-chlorobenzyl bromide according to Method B2a to give N-(4-chlorobenzyl)-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-(4-chlorobenzyl)-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 2-chloro-4-cyanophenyl isothiocyanate to give 2-(2-chloro-4-cyanophenylimino)-3-(4-chlorobenzyl)-1,3-thiazolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-8c2e3d03f9ce471aaa3fd02c61e88840 |
| Source note | uspto-grants-2002_03 |