反应详情

540 mg (≃0.002 mole) of ##STR17## C5H11 and 700 mg (≃0.002 mole) of 3-bromo-4 octyloxybenzoic acid chloride are charged in a reactor containing 10 ml of pyridine and kept at ambient temperature for 48 hours. The reaction mixture is then poured into a solution containing 10 ml of concentrated H2SO4 and 100 g of ice. The organic fraction is extracted three times with ether then washed three times with water and finally dried on anhydrous Na2SO4. The solvent is evaporated and the product is recrystallised three times in ethanol. 850 ml of product are obtained. The molar efficiency is 73%. Step (d) of substituting the cyanide group for the bromine group

1. additionThe reaction mixture is then poured into a solution
2. extractionThe organic fraction is extracted three times with ether
3. washthen washed three times with water
4. dry with materialfinally dried on anhydrous Na2SO4
5. customThe solvent is evaporated
6. customthe product is recrystallised three times in ethanol