L-Leucinol → HCID 178426704, Verbindung

HRID 276440Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 276440
O[CH2:2][C@@H:3]([NH2:8])[CH2:4][CH:5]([CH3:7])[CH3:6].[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=1[N:19]=[C:20]=[S:21]>>[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=1[N:19]=[C:20]1[NH:8][C@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[CH2:2][S:21]1

Komponenten

3

Edukt 2

HCID 111307L-LeucinolHCID 27599552-Isothiocyanato-1-methyl-4-nitrobenzene

Produkt 1

HCID 178426704HCID 178426704, Verbindung

Versuchsvorschrift

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was converted to (1R)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 2-Methyl-5-nitrophenyl isothiocyanate was reacted with (1R)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4R)-2-(2-methyl-5-nitrophenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with methyl iodide according to Method D2a to afford (4R)-2-(2-methyl-5-nitrophenylimino)-4-isobutyl-3-methyl-1,3-thiazolidine HCl salt.

Quellen und Nachweise

ORD-Eintrag
ord-af799b0cbfc547b488db02724c6f74b0
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353006B1

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