HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | L-Leucinol | HCID 111307 | — |
| Reactant | 2-Ethyl-4-cyanophenyl isothiocyanate | HCID 18316102 | — |
| Product | (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine | HCID 178436590 | — |
Reaction Steps
(1S)-1-(Hydroxymethyl)-3-methylbutylamine was reacted with SOCl2 followed by 4-cyano-2-ethylphenyl isothiocyanate according to Method C2a to give (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-cyano-2-ethylphenylimino)-3,4-diisobutyl-1,3-thiazolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-729bc953ecec46e080796b4cb27e7f59 |
| Source note | uspto-grants-2002_03 |