2-Methyl-4-nitrophenyl isothiocyanate → HCID 178455883, compound

Participants

Reaction Steps

(1S,2S)-1-(Hydroxymethyl)-2-methylbutylamine was converted to (1S,2S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S,2S)-1-(chloromethyl)-2-methylbutanammonium chloride according to Method C1a to give (4S)-2-(2-methyl-4-nitrophenylimino)-4-((2S)-2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(2-methyl-4-nitrophenylimino)-4-((2S)-2-butyl)-3-isobutyl-1,3-thiazolidine HCl salt.

Provenance & Evidence