1-Bromo-2-methylpropane → HCID 54180031, compound

HRID 276491Notes

Reaction equation

HRID 276491 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[NH:16][C@H:15]([CH:17]([CH3:19])[CH3:18])[CH2:14][S:13]1.[CH2:20](Br)[CH:21]([CH3:23])[CH3:22]>>[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[N:16]([CH2:20][CH:21]([CH3:23])[CH3:22])[C@H:15]([CH:17]([CH3:19])[CH3:18])[CH2:14][S:13]1

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 178428756HCID 178428756, compound

Product 1

HCID 54180031HCID 54180031, compound

Procedure

(1R)-1-Isopropyl-2-hydroxyethylamine was reacted with SOCl2 followed by 2-Methyl-4-nitrophenyl isothiocyanate according to Method C2a to give (4R)-2-(2-methyl-4-nitrophenylimino)-4-isopropyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4R)-2-(2-methyl -4-nitrophenylimino)-4-isopropyl-3-isobutyl-1,3-thiazolidine.

Sources & evidence

ORD record
ord-bb8a295c7b55464086d52c0e37463e51
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Reaction notes

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