HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-4-nitrophenyl isothiocyanate → (4S)-2-(2-methyl-4-nitrophenylimino)-4-benzyl-1,3-thiazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-4-nitrophenyl isothiocyanate | HCID 145621 | — |
| Reactant | phenylalaninol, (S)- | HCID 447213 | — |
| Reactant | (1S)-2-chloro-1-benzylethylammonium chloride | HCID 69994545 | — |
| Product | (4S)-2-(2-methyl-4-nitrophenylimino)-4-benzyl-1,3-thiazolidine | HCID 178428750 | — |
Reaction Steps
(1S)-1-Benzyl-2-hydroxyethylamine was converted to (1S)-2-chloro-1-benzylethylammonium chloride according to Method B7b. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S)-2-chloro-1-benzylethylammonium chloride according to Method C1a to give (4S)-2-(2-methyl-4-nitrophenylimino)-4-benzyl -1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(2-methyl-4-nitrophenylimino)-4-benzyl-3-isobutyl-1,3-thiazolidine HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-8c786e54648547e4985475ba26491c67 |
| Source note | uspto-grants-2002_03 |