HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (4R)-2-(2-methyl-4-nitrophenylimino)-4-(methoxycarbonyl)-3-isobutyl-1,3-thiazolidine HCl salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methyl-4-nitrophenyl isothiocyanate | HCID 145621 | — |
| Reactant | (S)-methyl 2-amino-3-hydroxypropanoate | HCID 2723731 | — |
| Reactant | (S)-N-isobutylserine methyl ester HCl salt | HCID 88094397 | — |
| Product | (4R)-2-(2-methyl-4-nitrophenylimino)-4-(methoxycarbonyl)-3-isobutyl-1,3-thiazolidine HCl salt | HCID 69994613 | — |
Reaction Steps
(S)-N-isobutylserine methyl ester HCl salt was made from (L)-serine methyl ester as described in Method B3a. The ester was reacted with SOCl2, followed by 2-methyl-4-nitrophenyl isothiocyanate according to Method C2a to afford (4R)-2-(2-methyl-4-nitrophenylimino)-4-(methoxycarbonyl)-3-isobutyl-1,3-thiazolidine HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-069d3b1248c444d1a4018f78e2e393a5 |
| Source note | uspto-grants-2002_03 |