Cyclohexanecarboxaldehyde → HCID 18316240, compound

HRID 276514Notes

Reaction equation

[CH3:1][C:2]([OH:6])([CH3:5])[CH2:3][NH2:4].[CH:7]1([CH:13]=O)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1>>[CH:7]1([CH:13]2[NH:4][CH2:3][C:2]([CH3:5])([CH3:1])[O:6]2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

Reactant 2

HCID 16275Cyclohexanecarboxaldehyde

HCID 951022-Propanol, 1-amino-2-methyl-

Product 1

HCID 18316240HCID 18316240, compound

Procedure

2-Methyl-2-hydroxypropylamine was reacted with cyclohexanecarboxaldehyde according to Method B4c, Step 1 to give 2-cyclohexyl-5,5-dimethyl-1,3-oxazolidine. The oxazolidine was reduced according to Method B4c, Step 2 to give N-cyclohexyl-2-methyl-2-hydroxypropylamine. The propanolamine was reacted with SOCl2 followed by 2,6-dichlorophenyl isothiocyanate according to Method C2f to afford 2-(2,6-dichlorophenylimino)-3-cyclohexyl-5,5-dimethyl-1,3-thiazolidine.

Sources & evidence

ORD record: ord-1ba7e85d54a64dab8b2306ba4c3b919c
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06353006B1

Reaction notes

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