Thionyl Chloride → HCID 18315994, compound

HRID 276537Notes

Reaction equation

[CH:1]([NH:4][CH2:5][C:6]([CH3:9])([CH3:8])O)([CH3:3])[CH3:2].O=S(Cl)Cl.[CH3:14][C:15]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=1[N:24]=[C:25]=[S:26]>>[CH3:14][C:15]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=1[N:24]=[C:25]1[N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][C:6]([CH3:9])([CH3:8])[S:26]1

Participants

Reactant 3

HCID 24386Thionyl Chloride

HCID 97503NSC 128243

HCID 1456212-Methyl-4-nitrophenyl isothiocyanate

Product 1

HCID 18315994HCID 18315994, compound

Procedure

Isopropylamine was reacted with 1,2-epoxy-2-methylpropane according to Method B5b to give N-isopropyl-N-(2,2-dimethyl-2-hydroxyethyl)amine. N-Isopropyl-N-(2,2-dimethyl-2-hydroxyethyl)amine was reacted with SOCl2 followed by 2-methyl-4-nitrophenyl isothiocyanate according to Method C2f to afford 2-(2-methyl-4-nitrophenylimino)-3-isopropyl-5,5-dimethyl-1,3-thiazolidine.

Sources & evidence

ORD record: ord-46607599a2a64b899adbe2ed0f7b914e
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06353006B1

Reaction notes

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