참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | 2-Propylaniline | HCID 15759 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-Iodo-2-n-propylaniline | HCID 10515532 | — |
| 반응물 | 4-Iodo-2-n-propylphenyl isothiocyanate | HCID 18316247 | — |
| 생성물 | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| 생성물 | 1-(Chloromethyl)cyclopentan-1-amine hydrochloride | HCID 69992485 | — |
반응 단계
2-n-Propylaniline was converted to 4-iodo-2-n-propylaniline according to Method A5a. The aniline was converted to 4-iodo-2-n-propylphenyl isothiocyanate according to Method A2b. 1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7a to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. The 2-chloroethylamine was reacted with 4-iodo-2-n-propylphenyl isothiocyanate according to Method C1a to give 2-(4-iodo-2-n-propylphenylimino)-1-thia-3-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method D2b to give 3-cyclopentyl-2-(4-iodo-2-n-propylphenylimino)-1-thia-3-azaspiro[4.4]nonane. The phenyl iodide was reacted with CuCN according to Method D7a to afford 3-cyclopentyl-2-(4-cyano-2-n-propylphenylimino)-1-thia-3-azaspiro[4.4]nonane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06353006B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_03 |
|---|
| ORD ID | ord-19a83d802be04ced89d022ac8783c61c |
|---|
| 출처 메모 | uspto-grants-2002_03 |
|---|
