反应详情

To a stirred mixture of 4-amino-3-methylphenol (24 g, 0.2 mole) in 600 ml of pyridine was added all at once p-nitrobenzenesulfonyl chloride (Eastman) (45 g, 0.2 mole) followed by heating on a steam bath for 2 hours. The dark oily solution was poured into 4 liters of water and then treated with glacial acetic acid until acid. The tar crystallized on standing to give after filtration 67 g (100%) of brown solid. The entire sample was recrystallized from CH3NO2 to give 52 g of pure intermediate.

1. temperatureby heating on a steam bath for 2 hours
2. customThe tar crystallized
3. customto give
4. filtrationafter filtration 67 g (100%) of brown solid
5. customThe entire sample was recrystallized from CH3NO2