1-Bromo-2-methylpropane → HCID 18316224, compound

HRID 276575Notes

Reaction equation

HRID 276575 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]2[NH:14][CH2:13][C:12]3([CH2:18][CH2:17][CH2:16][CH2:15]3)[S:11]2)=[C:5]([CH3:19])[CH:4]=1)#[N:2].[CH2:20](Br)[CH:21]([CH3:23])[CH3:22]>>[CH2:20]([N:14]1[CH2:13][C:12]2([CH2:15][CH2:16][CH2:17][CH2:18]2)[S:11][C:10]1=[N:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][C:5]=1[CH3:19])[CH:21]([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 178426454HCID 178426454, compound

Product 1

HCID 18316224HCID 18316224, compound

Procedure

1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7a to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. The 2-chloroethylamine was reacted with 4-cyano-2-ethylphenyl isothiocyanate according to Method C1a to give 2-(4-cyano-2-methylphenylimino)-1-thia-3-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2b to give 3-isobutyl-2-(4-cyano-2-methylphenylimino)-1-thia-3-azaspiro[4.4]nonane.

Sources & evidence

ORD record
ord-0138960f4d914afda95b7d916e6bb180
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Reaction notes

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