Ethanolamine → 1-Aminocyclopentanemethanol
반응식
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH2:9][CH2:10][CH3:11])[CH:3]=1.IC1C=[CH:17][C:16]([N:19]=[C:20]=[S:21])=[C:15]([CH2:22][CH2:23][CH3:24])C=1.[OH:25]CCN.O=S(Cl)Cl>>[OH:25][CH2:7][C:5]1([NH2:6])[CH2:4][CH2:9][CH2:10][CH2:11]1.[I:1][C:2]1[CH:8]=[CH:7][C:5]([N:6]=[C:20]2[S:21][CH2:17][C:16]3([CH2:15][CH2:22][CH2:23][CH2:24]3)[NH:19]2)=[C:4]([CH2:9][CH2:10][CH3:11])[CH:3]=1참가 물질
6
실험 절차
4-Iodo-2-n-propylaniline was converted to 4-iodo-2-n-propylphenyl isothiocyanate according to Method A2b. 1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was sequentially reacted with SOCl2 and 4-iodo-2-n-propylphenyl isothiocyanate according to Method C2a to give 2-(4-iodo-2-n-propylphenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method D2b to give 2-(4-iodo-2-n-propylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane. The phenyl iodide was reacted with CuCN according to Method D7a to afford 2-(4-cyano-2-n-propylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
출처 및 근거
- ORD 기록
- ord-b94cc4b2122a470595f2a9a5116d86f5
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06353006B1
반응 노트
불러오는 중…