HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 1-Aminocyclopentanemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Iodo-2-(propan-2-yl)aniline | HCID 12667938 | — |
| Reactant | 4-Iodo-2-isopropylphenyl isothiocyanate | HCID 18316506 | — |
| Product | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| Product | HCID 178439352 | HCID 178439352 | — |
Reaction Steps
4-Iodo-2-isopropylaniline was converted to 4-iodo-2-isopropylphenyl isothiocyanate according to Method A2b. 1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was sequentially reacted with SOCl2 and 4-iodo-2-isopropylphenyl isothiocyanate according to Method C2a to give 2-(4-iodo-2-isopropylphenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method D2b to give 2-(4-iodo-2-isopropylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane. The phenyl iodide was reacted with CuCN according to Method D7a to afford 2-(4-cyano-2-isopropylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-e7fd45ebbf7d426ba8c5e5f6e2cdeb76 |
| Source note | uspto-grants-2002_03 |