関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 4-Cyano-2-methylphenyl isothiocyanate | HCID 18316299 | — |
| 反応物 | 1-(Chloromethyl)cyclopentan-1-amine hydrochloride | HCID 69992485 | — |
| 生成物 | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| 生成物 | 4-Amino-3-methylbenzonitrile | HCID 7010316 | — |
| 生成物 | 2-(4-Cyanophenylphenylimino)-3-thia-1-azaspiro[4.4]nonane | HCID 178509561 | — |
反応手順
4-Cyano-2-methylaniline was prepared according to Method A1a. The aniline was converted to 4-cyano-2-methylphenyl isothiocyanate according to Method A2b. 1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was converted to 1-chloromethylcyclopentanamine HCl salt according to Method B7e. 1-Chloromethylcyclopentanamine HCl salt was reacted with 4-cyano-2-methylphenyl isothiocyanate according to Method C1e to give 2-(4-cyanophenylphenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method D2b to give 2-(4-cyano-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane. The nitrile was hydrolyzed according to Method D9a to afford 2-(4-carboxy-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06353006B1 |
|---|
| 出典データセット | uspto-grants-2002_03 |
|---|
| ORD ID | ord-be2fe4b724b24980a0d8ae8b7f51af2f |
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| 出典メモ | uspto-grants-2002_03 |
|---|
