HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 1-Aminocyclopentanemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Bromo-1-isothiocyanato-2-methylbenzene | HCID 87977 | — |
| Product | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| Product | HCID 178422439 | HCID 178422439 | — |
Reaction Steps
1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was sequentially reacted with SOCl2 and 4-bromo-2-methylphenyl isothiocyanate according to Method C2a to give 2-(4-bromo-2-methylphenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method1 D2b to give 2-(4-bromo-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-fdcc42809fd44ce581b1776076721744 |
| Source note | uspto-grants-2002_03 |