HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromocyclopentane → 2-(4-Bromo-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromocyclopentane | HCID 8728 | — |
| Reactant | HCID 178422439 | HCID 178422439 | — |
| Product | 2-(4-Bromo-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane | HCID 18316535 | — |
Reaction Steps
1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was sequentially reacted with SOCl2 and 4-bromo-2-methylphenyl isothiocyanate according to Method C2a to give 2-(4-bromo-2-methylphenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cyclopentyl bromide according to Method1 D2b to give 2-(4-bromo-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-7c7685f47ae143b19e7b6e08f9466947 |
| Source note | uspto-grants-2002_03 |