HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 1-Aminocyclopentanemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methyl-4-nitrophenyl isothiocyanate | HCID 145621 | — |
| Product | 1-Aminocyclopentanemethanol | HCID 66307 | — |
| Product | 2-(2-Methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane | HCID 178428736 | — |
Reaction Steps
1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was sequentially reacted with SOCl2 and 2-methyl-4-nitrophenyl isothiocyanate according to Method C2a to give 2-(2-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with cycloheptyl bromide according to Method D2e to give 2-(2-methyl-4-nitrophenylimino)-1-cycloheptyl-3-thia-1-azaspiro [4.4]nonane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-1921f0e9778349cebbca4990199f2e21 |
| Source note | uspto-grants-2002_03 |