Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbamate → (1-Aminocyclohexyl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbamate | HCID 276 | — |
| 반응물 | Benzyl carbamate | HCID 12136 | — |
| 반응물 | 1-(Cbz-amino)cyclohexanecarboxylic acid | HCID 11357886 | — |
| 반응물 | benzyl N-[1-(hydroxymethyl)cyclohexyl]carbamate | HCID 18316421 | — |
| 생성물 | (1-Aminocyclohexyl)methanol | HCID 409153 | — |
반응 단계
1-Amninocyclohexane-1-carboxylic acid was protected as the benzyloxycarbonylamine according to Method B1a, Step 1. 1-(Benzyloxycarbonylamino)cyclohexane-1-carboxylic acid was reduced to 1-(benzyloxycarbonylamino)-1-(hydroxymethyl)cyclohexane according to Method B1a, Step 2. The carbamate was deprotected according to Method B1a, Step 3 to give 1-amino-1-(hydroxymethyl)cyclohexane. The 2-hydroxyethylamine was sequentially treated with SOCl2 and 2-methyl-4-nitrophenyl isothiocyanate according to Method C2a to give 2-(2-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.5]decane. The thiazolidine was alkylated with isobutyl bromide according to Method D2b to afford 2-(2-methyl-4-nitrophenylimino)-1-isobutyl-3-thia-1-azaspiro[4.5]decane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06353006B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-68947df579af400a92afd85182b4ceec |
| 출처 메모 | uspto-grants-2002_03 |