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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 276672Generated: October 26, 2026

Chloroacetic Acid → 2-(2-methyl-4-nitrophenylimino)-3-((1R)-1-cyclohexylethyl)-1,3-thiazolidin-4-one

https://huagongshe.com/reaction/276672

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloroacetic AcidHCID 300—
Reactant2-Methyl-4-nitrophenyl isothiocyanateHCID 145621—
Reactant(-)-1-CyclohexylethylamineHCID 10997046—
Product2-(2-methyl-4-nitrophenylimino)-3-((1R)-1-cyclohexylethyl)-1,3-thiazolidin-4-oneHCID 22951217—

Reaction Steps

2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1R)-1-amino-1-cyclohexylethane followed by chloroacetic acid according to Method C8a to afford 2-(2-methyl-4-nitrophenylimino)-3-((1R)-1-cyclohexylethyl)-1,3-thiazolidin4-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06353006B1
Source datasetuspto-grants-2002_03
ORD IDord-3ae35799dd82453a884ef20e8c23bc65
Source noteuspto-grants-2002_03