1-Bromo-2,2-dimethylpropane → (4S)-2-(N-(2,2-dimethylpropyl)-2-methyl-4-nitrophenylamino)-4-isobutyl-1,3-thiazoline

HRID 276703노트

반응식

HRID 276703 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[NH:16][C@@H:15]([CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:14][S:13]1.[CH2:21](Br)[C:22]([CH3:25])([CH3:24])[CH3:23]>>[CH3:21][C:22]([CH3:25])([CH3:24])[CH2:23][N:11]([C:3]1[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=1[CH3:1])[C:12]1[S:13][CH2:14][C@H:15]([CH2:17][CH:18]([CH3:20])[CH3:19])[N:16]=1

참가 물질

3

반응물 2

HCID 124151-Bromo-2,2-dimethylpropaneHCID 178428753HCID 178428753, 화합물

생성물 1

HCID 22951235(4S)-2-(N-(2,2-dimethylpropyl)-2-methyl-4-nitrophenylamino)-4-isobutyl-1,3-thiazoline

실험 절차

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4S)-2-(2-methyl-4nitrophenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with neopentyl bromide according to Method D2a to afford (4S)-2-(N-(2,2-dimethylpropyl)-2-methyl-4-nitrophenylamino)-4-isobutyl-1,3-thiazoline.

출처 및 근거

ORD 기록
ord-45d63d42b60741d0ac273f442a8f78d0
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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