Diisopropylethylamine → HCID 145832747, compound

Participants

Reaction Steps

A mixture 1H-pyrrole-1-carboxamidine hydrochloride (4.40 g, 30 mmol), N-tert-butoxycarbonyl piperazine (5.59 g, 30 mmol) and N,N-diisopropylethylamine (6.3 mL, 36 mmol) in 2-propanol (50 mL) was refluxed for 24 h, cooled to room temperature and the solvents were removed under reduced pressure. The residue was suspended in acetonitrile (50 mL) and filtered; the white precipitate was washed with acetonitrile (50 mL) and dried under vacuum to yield N-tert-butoxycarbonyl piperazine-1-carboxamidine (6.20 g).

Provenance & Evidence