Hydrochloric Acid → HCID 22464567, compound

Participants

Reaction Steps

14.7 g (82.7 mM) of bis(2-chloroethyl)amine×HCl were added to 13.0 g (82.7 mM) of 1-amino-2-methylnaphthalene in 100 ml of chlorobenzene and refluxed under nitrogen for 90 h. The mixture was then concentrated and partitioned between methylene chloride and water at pH=9, and the organic phase was dried and concentrated. The crude product was purified by column chromatography (silica gel, mobile phase/THF/methanol/ammonia 85/13/2. 11.6 g (62%) of product were isolated.

Provenance & Evidence