3-Chloro-4-fluoroaniline → 4-(3-Chloro-4-fluoro-phenylamino)-6-nitro-[1.8]naphthyridine-3-carbonitrile

Participants

Reaction Steps

By using the method of Example 21, 2.5 g (10.66 mmol) of 4-chloro-6-nitro-[1.8]naphthyridine-3-carbonitrile and 1.55 g (10.66 mmol) of 3-chloro-4-fluoro-aniline was converted to 3.51 g of the title compound, a yellow solid, as its hydrochloride salt: mass spectrum (electrospray, m/e): M+H 344.1.

Provenance & Evidence