3-Bromoaniline → HCID 18548941, compound

Participants

Reaction Steps

To the above 600 mg of 4,6-dichloro-[1.7]naphthyridine-3-carbonitrile in 20 mL of absolute ethanol was added 1 mL of 3-bromoaniline. After refluxing the reaction under an inert atmosphere for 4 hours, the reaction mixture was cooled to ambient temperature, diluted with ether, and the product was filtered and washed with ether. Drying in vacuo yielded 790 mg of 4-(3-bromo-phenylamino)-6-chloro-[1.7]naphthyridine-3-carbonitrile as an off-white solid: mp=220-223° C.; mass spectrum (m/e): M+H 359.0, 361.1.

Provenance & Evidence