4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride → 4-Phenylpiperidinium chloride

HRID 276883ノート

反応式

HRID 276883 の反応式
[ClH:1].[C:2]1([C:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>CO.[C].[Pd]>[ClH:1].[C:2]1([CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 27238604-Phenyl-1,2,3,6-tetrahydropyridine hydrochlorideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 825094-Phenylpiperidinium chloride収率 95%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

1,2,3,6-Tetrahydro-4-phenylpyridine hydrochloride (200 mg, 1.0 mmol) and 10% palladium-carbon (30 mg) were stirred in methanol (2 ml) for 19 hours in an atmosphere of hydrogen. The reaction solution was filtered and the resulting residue was thoroughly washed with methanol. Then the filtrate and washed solution were combined and evaporated under a reduced pressure to obtain 190 mg of the title compound (0.95 mmol, 93% in yield).

後処理

  1. filtrationThe reaction solution was filtered
  2. washthe resulting residue was thoroughly washed with methanol
  3. washThen the filtrate and washed solution
  4. customevaporated under a reduced pressure

出典と根拠

ORDレコード
ord-f17c9e4ce6a940b093b51a92cdce4483
出典データセット
uspto-grants-2002_03
特許番号
US06355642B1

反応ノート

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