HCID 178426378, compound → HCID 178423450, compound

HRID 27691Notes

Reaction equation

HRID 27691 reaction equation
[C:1]1([CH3:16])[CH:6]=[CH:5][C:4]([NH:7][C:8]2[N:9]=[N:10][NH:11][C:12]=2[C:13]([OH:15])=O)=[CH:3][CH:2]=1>CCO.CN(C=O)C.O>[CH3:16][C:1]1[CH:2]=[CH:3][C:4]2[NH:7][C:8]3[N:9]=[N:10][NH:11][C:12]=3[C:13](=[O:15])[C:5]=2[CH:6]=1

Participants

3

Reactant 1

HCID 178426378HCID 178426378, compound

Product 1

HCID 178423450HCID 178423450, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 86633292ethanol water DMFSolvent

Procedure

Cyclisation of 4-(p-tolylamino)-1,2,3-triazole-5-carboxylic acid (1 g) with 85% polyphosphoric acid (12 g) at 100° C. over 2 hrs. gave 0.66 g (72%) of the title compound of mp (EtOH-DMF-H2O) 310° C.; νmax (mull) 2720 (br.) 1655, 1600 cm-1, Δ (DMSO) 2.42 (3H, s); 7.58 (2H, s); 8.10 (1H,s), 1 low fieled broad (exchangeable). (Found; C, 59.89; H, 4.37; N, 28.09; C10H8N4O2 requires; C, 59.99 H, 4.03; N, 27.99%).

Sources & evidence

ORD record
ord-945e585036eb480da2d4a8bf3b485642
Source dataset
uspto-grants-1980_09
Patent number
US04223032

Reaction notes

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