Sodium Hydroxide → HCID 22629171, compound

Participants

Reaction Steps

A mixture of 3-[2-{2-(2-benzyloxycarbonylethyl)-1-cyclohexenyl}-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine (74 mg) and 1N-sodium hydroxide (0.28 ml) in tetrahydrofuran (4 ml) was refluxed with stirring for 5 hours. The mixture was evaporated under reduced pressure. The residue was dissolved in water. The aqueous layer was washed with ethyl acetate, acidified with 1N-hydrochloric acid and extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate and evaporated under reduced pressure. The residue was recrystallized from ethanol-water to give 3-[2-{2-(2-carboxyethyl)-1-cyclohexenyl}-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]-pyridine (54 mg).

Provenance & Evidence